Corneal Nerve Abnormalities in Ocular and Systemic Diseases

The trigeminal nerve gives rise to the corneal subbasal system, which plays a crucial role in sensations of touch, pain, and temperature ocular healing processes. Technological advancements instruments, particular vivo confocal microscopy aethesiometry, have allowed for structural functional evaluation nerves health disease. Through application these technologies humans animal models, abnormalities been detected several systemic disorders, including dry eye disease (DED), glaucoma, migraine, fibromyalgia. However, studies across number conditions found that do not always relate abnormalities. This review will discuss instruments used evaluate summarize data on conditions. Furthermore, it potential treatments can alleviate main manifestations dysfunction, namely surface pain persistent epithelial defects.